Synopsis  

As middle schooler Emily Elizabeth struggles to fit in at home and at school, she discovers a small red puppy who is destined to become her best friend from a magical animal rescuer. When Clifford becomes a gigantic red dog in her New York City apartment and attracts the attention of a genetics company who wish to supersize animals, Emily and her clueless Uncle Casey have to fight the forces of greed as they go on the run across New York City.